Promising natural products against SARS-CoV-2: Structure, function, and clinical trialsArticle Published on 2022-10-012022-11-15 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 activity acute respiratory syndrome addition analyzed antiinflammatory antivirals assessments Breakthrough infection caused clinical trial clinical trials coronavirus Coronaviruses COVID-19 Critical drug drug interaction drugs Effect effective enhancer Health immune Improvements inhibitory effect mechanism Mutation natural products. Protein RdRP Research SARS-CoV-2 shown Spread Structure structures Vaccine virus Virus Disease [DOI] 10.1002/ptr.7580 PMC 바로가기
Long-lasting, dissociable improvements in working memory and long-term memory in older adults with repetitive neuromodulation Research Published on 2022-08-222022-10-05 Journal: Nature Neuroscience [Category] 유전자 메커니즘, [키워드] baseline benefit Brain Cognitive function cortical ENhance improvement Improvements individual Intervention memory modulation Older parameter plasticity predicted PROTECT protocol selective synchronous translational [DOI] 10.1038/s41593-022-01132-3 [Article Type] Research
Identifying novel host-based diagnostic biomarker panels for COVID-19: a whole-blood/nasopharyngeal transcriptome meta-analysisCOVID-19에 대한 새로운 호스트 기반 진단 바이오마커 패널 식별: 전혈/비인두 전사체 메타 분석Meta-Analysis Published on 2022-08-032022-09-11 Journal: Molecular Medicine [Category] SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Accuracy acute respiratory illness acute respiratory illnesses analysis applied ARI bioinformatics Biomarker Blood Cell cell cycle Characteristics Combination complementary controls COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients COVID-19 sample cross cytokine cytokine production Data integration dataset Defense detect diagnose diagnostic diagnostic biomarker Diagnostic biomarkers Diseases eight enhancement feature gene expression profile Gene ontology HCs healthy control healthy controls Host host gene host response identifying Immune cell improvement Improvements independent indicated induce Infection Inflammatory interferon introduced lack machine learning algorithm Machine learning algorithms marker Meta-analysis nasopharyngeal Nasopharyngeal swab Ontology Pathogenesis pathway pathway enrichment patients with COVID-19 proportion Random forest respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis selected swab sample System Systems biology Transcriptome upregulation Viral virus Whole blood whole blood. [DOI] 10.1186/s10020-022-00513-5 PMC 바로가기 [Article Type] Meta-Analysis
Effect of Molnupiravir on Biomarkers, Respiratory Interventions, and Medical Services in COVID-19 : A Randomized, Placebo-Controlled Trial코로나19의 바이오마커, 호흡기 중재 및 의료 서비스에 대한 몰누피라비르의 효과 : 무작위, 위약 대조 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Annals of internal medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] 95% CI Analysis analysis assigned baseline benefit C-reactive protein C-reactive protein (CRP Care change clinical benefit clinically Concentration COVID-19 CRP death discharge discharged double-blind Effect evaluated faster Hospitalization Hospitalized identify immunized improvement Improvements Inc Invasive mechanical ventilation less LLC median medical service medical services Mild mild to moderate Mild to moderate COVID-19 Moderate COVID-19 molnupiravir Older oxygen oxygen saturation participant performed Phase 3 Placebo placebo-controlled placebo-treated participant placebo-treated participants potential clinical benefit progression randomization Randomized Randomly receiving reduction in Relative risk respiratory respiratory intervention respiratory interventions risk risk factor Risk factors risk reduction SARS-CoV-2 secondary service severe disease Sharp subsidiary therapy Trial [DOI] 10.7326/M22-0729 PMC 바로가기 [Article Type] Randomized Controlled Trial
Reconstruction of transmission chains of SARS-CoV-2 amidst multiple outbreaks in a geriatric acute-care hospital: a combined retrospective epidemiological and genomic study노인 급성 치료 병원에서 여러 번 발생하는 SARS-CoV-2의 전염 사슬 재구성: 역학 및 게놈 결합 후향적 연구Article Published on 2022-07-192022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 attack rate attack rates Bayesian Cluster coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 credible interval CrI determine Elderly patient elderly patients epidemiological evaluated event expected foundation Genetic genomic geriatric hospitals greater HCW HCWs healthcare worker Healthcare workers Healthcare-associated infection highlight hospital improvement Improvements Infection infection control Infection prevention Infectious disease involved late phase limit Medicine Microbiology MOST Non-COVID-19 patients nosocomial nosocomial COVID-19 nosocomial outbreak Nosocomial outbreaks Nosocomial transmission occurred outbreak pandemic Patient patients performed positive posterior probability proportion random ranged reconstructed reconstruction retrospective retrospective cohort study room SARS-CoV-2 SARS-CoV-2 RT-PCR Science secondary cases sequencing data severe acute respiratory syndrome Coronavirus spring statistically significant study period supported Transmission Transmission dynamics transmission pattern viruses viruses. ward [DOI] 10.7554/eLife.76854 PMC 바로가기 [Article Type] Article
Rapid and sensitive detection of viral particles by coupling redox cycling and electrophoretic enrichment산화환원 순환과 전기영동 농축을 결합하여 바이러스 입자를 신속하고 감도로 감지Article Published on 2022-07-152022-09-11 Journal: Biosensors & bioelectronics [Category] 치료기술, [키워드] amplification Amplification factor amplified Analysis calculate COVID-19 pandemic Critical Cycling droplet Early detection Effect Efficiency electric field Electrochemical sensor Electrophoresis Factor Field strength Frequency geometric IDE improvement Improvements magnitude mitigate MONITOR Outbreaks Particle Particle collision platform Rapid redox Redox cycling reduced viral loads viral particle virion virus virus detection virus. widespread [DOI] 10.1016/j.bios.2022.114198 PMC 바로가기 [Article Type] Article
Acquired insights from the long-term surveillance of SARS-CoV-2 RNA for COVID-19 monitoring: The case of Monterrey Metropolitan Area (Mexico)COVID-19 모니터링을 위한 SARS-CoV-2 RNA의 장기 감시에서 얻은 통찰력: 몬테레이 수도권(멕시코) 사례Article Published on 2022-07-012022-09-11 Journal: Environmental research [Category] COVID19(2023년), SARS, 치료기술, [키워드] Acquired Analysis applicability applied approach Area clinical testing Community complement COVID-19 demonstrated detection rate epidemiological Epidemiology estimate feasible hospital Improvements Interpretation median MONITOR offer outbreak plant positive Prevalence ranged reported Result room RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 viral load SARS-CoV-2 viral loads Spread statistical Surveillance tested Treatment Viral load viral titer viral titers wastewater Wastewater. [DOI] 10.1016/j.envres.2022.112967 PMC 바로가기 [Article Type] Article
Virtual respiratory therapy delivered through a smartphone app: a mixed-methods randomised usability study스마트폰 앱을 통해 전달되는 가상 호흡 요법: 혼합 방법 무작위 사용성 연구Article Published on 2022-06-012022-09-11 Journal: BMJ Open Respiratory Research [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] affecting arising artefact breath Breath sound chronic condition comparable COPD COPD exacerbations COVID-19 credibility cystic fibrosis detect dimension distance effective Effectiveness Efficiency effort Engagement evaluate exercise feature Features fibrosis Gamification healthy volunteer healthy volunteers improvement Improvements Incentive spirometry include less Look and feel management participant performed persistence Pneumonia postoperative preference proximal pulmonary rehabilitation questionnaire randomised randomised controlled trial Randomised controlled trials reduction in rehabilitation repeated reported Research respiratory infection respiratory infection. respiratory therapy SARS-CoV-2 Satisfaction selective spirometry therapy timer Usability [DOI] 10.1136/bmjresp-2022-001221 PMC 바로가기 [Article Type] Article
Heterogeneous SARS-CoV-2-Neutralizing Activities After Infection and Vaccination감염 및 예방 접종 후 이종 SARS-CoV-2-중화 활동Article Published on 2022-05-302022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus addition analyzed antibody Antibody Response Antibody responses best Beta Cohort coronavirus COVID-19 COVID-19 vaccination D614G declined decrease Delta dose exceeded greater heterogeneity Hospitalized hospitalized patient hospitalized patients Humoral immunity Immunity Improvements individual infected individual infected individuals infecting Infection lowest mRNA vaccine Mutation N-terminal domain neutralization neutralization titer neutralizing activities Neutralizing activity Neutralizing antibodies neutralizing antibody responses no difference not differ pandemic Patient patients Protein recognize respiratory SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-neutralizing antibodies SARS-CoV-2-specific antibody responses SARS-CoV-2-specific neutralizing antibodies second vaccination sequence serum sample serum samples severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly lower Specific specific neutralizing antibodies Spike protein symptom onset the SARS-CoV-2 the spike protein vaccinated individual vaccinated individuals Vaccine vaccinee vaccinees variants variants of concern variants of concern. viral strain viral strains virus infection VoC VOCs [DOI] 10.3389/fimmu.2022.888794 PMC 바로가기 [Article Type] Article
Evaluation of Host Protein Biomarkers by ELISA From Whole Lysed Peripheral Blood for Development of Diagnostic Tests for Active Tuberculosis활동성 결핵 진단 테스트 개발을 위한 전 용해 말초 혈액에서 ELISA에 의한 숙주 단백질 바이오마커 평가Article Published on 2022-05-202022-09-11 Journal: Frontiers in Immunology [Category] 바이오마커, [키워드] analyses assay associative barrier Biomarker Biomarkers blood sample CALCOCO2 capture cause of death caused CD274 CD52 collected combinations complex conducted confirmatory tests consequence Control correlation country COVID-19 pandemic death defined development diagnosing Diagnosis diagnostic diagnostic test differentially expressed disease Diversity downregulated ELISA ENhance eradication evaluate expression GBP1 group groups Health Health crisis IFIT3 IFITM3 improvement Improvements incidence India individuals infected individuals Infection Infectious disease information investigated Key priorities key priority Laboratory Lateral flow device lysed negative controls nine Patient peripheral profile Protein protein expression Protein target protein targets qPCR Rapid reducing required ROC SAMD9L significantly SNX10 Stratification Test the WHO Tuberculosis tuberculosis. validation study WHO World Health Organisation [DOI] 10.3389/fimmu.2022.854327 PMC 바로가기 [Article Type] Article